What tends to worsen with higher tolerance and dependence on a drug?

The correct answer focuses on how higher tolerance and dependence directly influence the effects of the drug. As individuals develop a tolerance to a substance, they often require larger doses to achieve the same effects they initially experienced. This heightened tolerance can lead to an increased intensity of the drug's effects, especially if the individual continues to consume higher quantities in pursuit of the desired euphoria or relief.

Individuals with a high degree of dependence may also find themselves experiencing a diminished response to the drug, creating a cycle where they feel compelled to consume more to feel "normal" or to overcome their dependency. This can result in dangerous situations, as they may not recognize how impaired they are, leading to greater risks during operation of vehicles or machinery, as well as increased potential for overdose.

Understanding this concept is crucial in recognizing the physical adaptations the body makes in response to continuous drug exposure, which can lead to escalating doses and ultimately exacerbate the user's condition and risks associated with their drug use.